Carbohydrate antigen 125 for mortality risk prediction following acute myocardial infarction.

Autor: Falcão F; Departamento de Medicina Interna, Universidade de Pernambuco (UPE), Garanhuns, PE, Brazil. felipejaf@gmail.com.; Unidade de Cardiologia Invasiva (UCI) - Hospital Memorial São José, Rede d'Or São Luiz, Recife, PE, Brazil. felipejaf@gmail.com., Oliveira F; Unidade de Cardiologia Invasiva (UCI) - Hospital Memorial São José, Rede d'Or São Luiz, Recife, PE, Brazil.; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Cantarelli F; Unidade de Cardiologia Invasiva (UCI) - Hospital Memorial São José, Rede d'Or São Luiz, Recife, PE, Brazil.; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Cantarelli R; Unidade de Cardiologia Invasiva (UCI) - Hospital Memorial São José, Rede d'Or São Luiz, Recife, PE, Brazil.; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Brito Júnior P; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Lemos H; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Silva P; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Camboim I; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Freire MC; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Carvalho O; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil., Sobral Filho DC; Pronto Socorro Cardiológico de Pernambuco (PROCAPE-UPE), Recife, PE, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Jul 03; Vol. 10 (1), pp. 11016. Date of Electronic Publication: 2020 Jul 03.
DOI: 10.1038/s41598-020-67548-8
Abstrakt: Carbohydrate antigen 125 (CA125) is a congestion and inflammation biomarker and has been proved to be related to a worse prognosis in heart diseases. However, the precise relationship between elevated CA125 in patients with ST-segment elevation myocardial infarction (STEMI) has not yet been sufficiently studied. We set out to determine the association of CA125 with all-cause mortality at 6 months in STEMI. CA125, N-terminal pro brain natriuretic peptide (NTproBNP) and high sensitive C-reactive protein (hs-CRP) were measured in 245 patients admitted consecutively with STEMI undergoing coronary angioplasty. The mean age in our sample was 63.7 years, 64.9% were males, 28.3% had diabetes and 17.7% presented with acute heart failure (Killip ≥ 2). The median serum level of CA125 was 8.1 U/ml. At 6 months, the rate of all-cause mortality was 18% (44 patients). Receiver operating characteristic curve analysis demonstrated that CA125 presented similar performance to predict mortality as NTproBNP and hs-CRP. Patients with CA125 ≥ 11.48 had a higher rate of mortality (Hazard Ratio = 2.07, 95% confidence interval = 1.13-3.77, p = 0.017) than patients with CA125 < 11.48. This study suggests that elevated CA125 levels might be used to identify patients with STEMI with a higher risk of death at 6 months. CA125 seems to be a similar predictor of mortality compared to NTproBNP and hs-CRP.
Databáze: MEDLINE
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