Translational quality control and reprogramming during stress adaptation.

Autor: Han NC; Department of Microbiology, The Ohio State University, Columbus, OH, 43220, USA., Kelly P; The Ohio State University Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, 43220, USA., Ibba M; Department of Microbiology, The Ohio State University, Columbus, OH, 43220, USA. Electronic address: ibba.1@osu.edu.
Jazyk: angličtina
Zdroj: Experimental cell research [Exp Cell Res] 2020 Sep 15; Vol. 394 (2), pp. 112161. Date of Electronic Publication: 2020 Jun 30.
DOI: 10.1016/j.yexcr.2020.112161
Abstrakt: Organisms encounter stress throughout their lives, and therefore require the ability to respond rapidly to environmental changes. Although transcriptional responses are crucial for controlling changes in gene expression, regulation at the translational level often allows for a faster response at the protein levels which permits immediate adaptation. The fidelity and robustness of protein synthesis are actively regulated under stress. For example, mistranslation can be beneficial to cells upon environmental changes and also alters cellular stress responses. Additionally, stress modulates both global and selective translational regulation through mechanisms including the change of aminoacyl-tRNA activity, tRNA pool reprogramming and ribosome heterogeneity. In this review, we draw on studies from both the prokaryotic and eukaryotic systems to discuss current findings of cellular adaptation at the level of translation, specifically translational fidelity and activity changes in response to a wide array of environmental stressors including oxidative stress, nutrient depletion, temperature variation, antibiotics and host colonization.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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