Effectiveness of strontium-doped brushite, bovine-derived hydroxyapatite and synthetic hydroxyapatite in rabbit sinus augmentation with simultaneous implant installation.

Autor: Lu DZ; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Zhang YB; Department of stomatology, Affiliated hospital of Chengde Medical College, Chengde City, Hebei Province, China., Dong W; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Bi WJ; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Feng XJ; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Wen LM; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Sun H; Department of pathology, college of basic medicine, North China University of Science and Technology, Tangshan City, Hebei Province, China., Chen H; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China., Zang LY; Department of Endocrinology (Section 1), Tangshan Gongren Hospital, Tangshan City, Hebei Province, China., Qi MC; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, Hebei Province, China.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2020 Nov; Vol. 108 (8), pp. 3402-3412. Date of Electronic Publication: 2020 Jul 03.
DOI: 10.1002/jbm.b.34675
Abstrakt: Various bone substitutes have been applied in sinus augmentation (SA) to overcome insufficient bone height at the posterior maxilla region caused by pneumatized sinus and severe alveolar bone resorption after teeth loss. However, their effectiveness in SA needs to be further elucidated. In this study, strontium-doped brushite (Sr-DCPD), a new bone substitute, together with bovine-derived hydroxyapatite (bHA) and synthetic hydroxyapatite (sHA) was used in rabbit maxillary SA with simultaneous implant installation. The sinus space-keeping capacity, resorption rate, osteoconductivity, and mechanical properties of regenerated bone, were evaluated by micro-computed tomography (CT), histological analysis, and mechanical testing. Sr-DCPD exhibited the best osteoconductivity and new bone formation (<4 weeks), but its final bone regeneration and removal torque of implants at week 12 were the lowest, mainly due to its poor space-keeping capacity and fast resorption. bHA exhibited the best space-keeping capacity and slowest resorption rate, but relative lower final bone volume and mechanical properties, while sHA showed good space-keeping capacity, slower resorption rate, and the best final bone formation and mechanical properties. sHA was most effective for SA and bHA was also an acceptable bone substitute; however, Sr-DCPD was least effective and not suitable in SA by itself.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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