Enalapril and treadmill running reduce adiposity, but only the latter causes adipose tissue browning in mice.

Autor: Giori IG; Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Magliano DC; Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Alexandre-Santos B; Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.; Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Fernandes T; National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.; Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, São Paulo, State of São Paulo, Brazil., Oliveira EM; National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.; Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, São Paulo, State of São Paulo, Brazil., Vieira CP; Department of Food Technology, Faculty of Veterinary, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Conte-Junior CA; Department of Food Technology, Faculty of Veterinary, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil., Ceddia RB; Muscle Health Research Center, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada., Nobrega ACL; Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.; National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil., Frantz EDC; Laboratory of Exercise Sciences, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.; Laboratory of Morphological and Metabolic Analyses, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.; National Institute for Science and Technology, INCT Physical (In)activity and Exercise, CNPq, Niteroi, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2021 Feb; Vol. 236 (2), pp. 900-910. Date of Electronic Publication: 2020 Jul 02.
DOI: 10.1002/jcp.29900
Abstrakt: This study investigated whether regulation of the renin-angiotensin system (RAS) by enalapril and/or aerobic exercise training (AET) causes browning of the subcutaneous white adipose tissue (sWAT). C57BL/6 mice were fed either a standard chow or a high-fat (HF) diet for 16 weeks. At Week 8, HF-fed animals were divided into sedentary (HF), enalapril (HF-E), AET (HF-T), and enalapril plus AET (HF-ET) groups. Subsequently, sWAT was extracted for morphometry, determination of RAS expression, and biomarkers of WAT browning. The HF group displayed adipocyte hypertrophy and induction of the classical RAS axis. Conversely, all interventions reduced adiposity and induced the counterregulatory RAS axis. However, only AET raised plasma irisin, increased peroxisome proliferator-activated receptor-γ coactivator-1α, and uncoupling protein-1 levels, and the expression of PR-domain containing 16 in sWAT. Therefore, we concluded that AET-induced sWAT browning was independent of the counterregulatory axis shifting of RAS in HF diet-induced obesity.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: