Health-related quality of life of women after HPV testing as triage strategy for an abnormal Pap smear: a nested randomized pragmatic trial in a middle-income country.

Autor: Urrea Cosme Y; Grupo Atropos, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia., Córdoba Sánchez V; Grupo Atropos, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia., Sánchez GI; Grupo Infección y Cáncer, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia., Baena A; Prevention and Implementation Group, International Agency for Research on Cancer / World Health Organization (IARC/WHO), 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France., Ruiz Osorio MA; Grupo Atropos, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia., Rodríguez Zabala D; Grupo Atropos, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia., Garcés-Palacio IC; Grupo de Epidemiología, Facultad Nacional de Salud Pública, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. icristina.garces@udea.edu.co.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2020 Nov; Vol. 29 (11), pp. 2999-3008. Date of Electronic Publication: 2020 Jul 02.
DOI: 10.1007/s11136-020-02563-w
Abstrakt: Background: Information obtained in studies on the impact of human papilloma virus (HPV) testing on health-related quality of life is contradictory.
Objective: To assess the impact on health-related quality of life of the HPV test, colposcopy, and cytology as triage strategies after a cytology with atypical squamous cells of undetermined significance (ASCUS) in Medellín, Colombia.
Methods: We carried out a nested analysis on the randomized pragmatic trial (ASCUS-COL). Women with ASCUS were assigned randomly to one of the 3 arms (Pap smear, colposcopy, HPV). Participants completed a questionnaire at baseline, two weeks after receiving the results of the triage tests and one year after the second questionnaire. We used the SF-36 to assess health-related quality of life.
Results: The sum score of the physical health component (PHC) and mental health component (MHC) increased significantly over time for the whole sample and there were no statistically significant differences between arms of PHC = survey 1: mean 52.4 (SD 8.21) vs. survey 3: mean 54.4 (SD 8.16) p < 0.0001 and of MHC = survey 1: mean 44.9 (SD 11.72) vs. survey 3: mean 48.1 (SD 11.20) p < 0.0001. A lower MHC occurred in women with lesser schooling, belonging to the public health care regimen, higher number of live births, and separated. A lower PHC was associated with the cytology arm, higher age, lesser schooling, and belonging to the subsidized regime. The risk of having depression went from 42% in the first survey to 26% in the third.
Conclusion: The triage strategies affected health-related quality of life in the same manner. ClinicalTrials.gov Identifier: NCT02067468.
Databáze: MEDLINE
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