Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood.

Autor:	Kaur S; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA., Sarma SJ; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; MU Metabolomics Center, University of Missouri, Columbia, MO, 65211, USA., Marshall BL; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA., Liu Y; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; MU Institute of Data Science and Informatics, University of Missouri, Columbia, MO, 65211, USA., Kinkade JA; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA., Bellamy MM; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA., Mao J; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA., Helferich WG; Food Science and Human Nutrition, University of Illinois, Urbana, IL, 61801, USA., Schenk AK; Physics, Randolph College, Lynchburg, VA, 24503, USA., Bivens NJ; DNA Core Facility, University of Missouri, Columbia, MO, 65211, USA., Lei Z; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; MU Metabolomics Center, University of Missouri, Columbia, MO, 65211, USA.; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, USA., Sumner LW; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; MU Metabolomics Center, University of Missouri, Columbia, MO, 65211, USA.; Department of Biochemistry, University of Missouri, Columbia, MO, 65211, USA., Bowden JA; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Environmental and Human Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA., Koelmel JP; Environmental Health Sciences, Yale University, New Haven, CT, 06510, USA., Joshi T; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.; MU Institute of Data Science and Informatics, University of Missouri, Columbia, MO, 65211, USA.; Department of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO, 65211, USA., Rosenfeld CS; Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA. rosenfeldc@missouri.edu.; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA. rosenfeldc@missouri.edu.; MU Institute of Data Science and Informatics, University of Missouri, Columbia, MO, 65211, USA. rosenfeldc@missouri.edu.; Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO, 65211, USA. rosenfeldc@missouri.edu.; Genetics Area Program, University of Missouri, Columbia, MO, 65211, USA. rosenfeldc@missouri.edu.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2020 Jul 02; Vol. 10 (1), pp. 10902. Date of Electronic Publication: 2020 Jul 02.
DOI:	10.1038/s41598-020-67709-9
Abstrakt:	Xenoestrogens are chemicals found in plant products, such as genistein (GEN), and in industrial chemicals, e.g., bisphenol A (BPA), present in plastics and other products that are prevalent in the environment. Early exposure to such endocrine disrupting chemicals (EDC) may affect brain development by directly disrupting neural programming and/or through the microbiome-gut-brain axis. To test this hypothesis, California mice (Peromyscus californicus) offspring were exposed through the maternal diet to GEN (250 mg/kg feed weight) or BPA (5 mg/kg feed weight, low dose- LD or 50 mg/kg, upper dose-UD), and dams were placed on these diets two weeks prior to breeding, throughout gestation, and lactation. Various behaviors, gut microbiota, and fecal metabolome were assessed at 90 days of age. The LD but not UD of BPA exposure resulted in individuals spending more time engaging in repetitive behaviors. GEN exposed individuals were more likely to exhibit such behaviors and showed socio-communicative disturbances. BPA and GEN exposed females had increased number of metabolites involved in carbohydrate metabolism and synthesis. Males exposed to BPA or GEN showed alterations in lysine degradation and phenylalanine and tyrosine metabolism. Current findings indicate cause for concern that developmental exposure to BPA or GEN might affect the microbiome-gut-brain axis.
Databáze:	MEDLINE
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