The influence of coffee intake and genetics on adenosine pathway in rheumatoid arthritis.

Autor:	Soukup T; 2nd Department of Internal Medicine - Gastroenterology, Division of Rheumatology, Charles University, Faculty of Medicine & University Hospital in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Hloch K; Department of Social & Clinical Pharmacy, Charles University, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Doseděl M; Department of Social & Clinical Pharmacy, Charles University, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Tebbens JD; Department of Biophysics & Physical Chemistry, Charles University, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Nekvindová J; University Hospital Hradec Kralove, Institute of Clinical Biochemistry and Diagnostics, Hradec Kralove, 50005, Czech Republic., Šembera Š; 2nd Department of Internal Medicine - Gastroenterology, Division of Rheumatology, Charles University, Faculty of Medicine & University Hospital in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Veleta T; Department of Emergency Medicine, Charles University, University Hospital in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Pávek P; Department of Pharmacology & Toxicology & Centre for Drug Development, Charles University, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, 50005, Czech Republic., Barvík I; Faculty of Mathematics & Physics, Institute of Physics, Charles University, Prague, 12116, Czech Republic.
Jazyk:	angličtina
Zdroj:	Pharmacogenomics [Pharmacogenomics] 2020 Jul; Vol. 21 (11), pp. 735-749. Date of Electronic Publication: 2020 Jul 03.
DOI:	10.2217/pgs-2020-0042
Abstrakt:	Aim: We studied the influence of coffee consumption on the therapeutic effect of methotrexate (MTX) in patients with rheumatoid arthritis (RA) sorted according to ADORA2A genotypes. Patients & methods: 82 RA patients were dichotomized according to caffeine intake with a threshold of 700 mg/week. Disease activity score 28 (DAS28) was applied (>3.2: high; <3.2: low or remission). Patients were genotyped using quantitative PCR allelic discrimination. Results: We found significantly higher risk of RA in patients with higher caffeine intake and the CT genotype of ADOARA2A rs2298383, rs3761422 and rs2267076 SNPs. The CC genotype of ADORA2A rs2236624 SNP in patients with lower caffeine intake treated with MTX is significantly protective. Conclusion: ADORA2A genotypes and coffee intake influence risk of RA and efficacy of it MTX treatment.
Databáze:	MEDLINE
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