Development of curcumin-loaded chitosan/pluronic membranes for wound healing applications.

Autor: Enumo A Jr; Polimat, Grupo de Estudos em Materiais Poliméricos, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil., Argenta DF; Laboratório de Farmacotécnica e Cosmetologia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil., Bazzo GC; Laboratório de Controle de Qualidade de Fármacos e Medicamentos, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil., Caon T; Laboratório de Farmacotécnica e Cosmetologia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil., Stulzer HK; Laboratório de Controle de Qualidade de Fármacos e Medicamentos, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil., Parize AL; Polimat, Grupo de Estudos em Materiais Poliméricos, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil. Electronic address: alexandre.parize@ufsc.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 15; Vol. 163, pp. 167-179. Date of Electronic Publication: 2020 Jun 29.
DOI: 10.1016/j.ijbiomac.2020.06.253
Abstrakt: The emergence of new materials with improved antibacterial, anti-inflammatory and healing properties compared to conventional wound dressings has both social and economic appeal. In this study, novel chitosan-based (CTS) membranes containing curcumin (CUR) incorporated in Pluronic (PLU) copolymers were developed and characterized to obtain suitable properties for applications as a wound healing dressing. The mechanical, thermal, swelling, wettability, release and permeation properties were evaluated by DSC, TGA, water contact angle measurements, FTIR, fluorescence and microscopic techniques. Membranes containing PLU and CUR presented wettability close to the ideal range for interaction with cellular components (contact angle ~40-70°), improved mechanical properties, higher thermal stability, high swelling degree (>800%) and CUR release (~60%) compared to samples without PLU addition. A higher retention of CUR in the epidermis than in the dermis layer was observed, which also was confirmed by confocal microscopy. Furthermore, the CTS-PLU membranes loaded with CUR showed to be active against Staphylococcus aureus and Pseudomonas aeruginosa (MIC = 25 and 100 mg mL -1 , respectively), the microbial species most present in chronic wounds. Overall, the CTS-PLU-CUR membranes presented suitable properties to act as a new wound healing dressing formulation and in vivo studies should be performed to confirm these benefits.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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