Differences in lung clearance index and functional residual capacity between two commercial multiple-breath nitrogen washout devices in healthy children and adults.

Autor:	Zwitserloot AM; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands., van den Born EJ; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands., Raaijmakers LHA; Radboud University Medical Center, Radboud Institute for Health Sciences, Dept of Primary and Community Care, Nijmegen, The Netherlands., Stalman WE; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands., van Smaalen M; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands., van den Berge M; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Dept of Pulmonary Diseases, Groningen, The Netherlands., Gappa M; Evangelisches Krankenhaus Düsseldorf, Children's Hospital, Düsseldorf, Germany., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands., Willemse BWM; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2020 Jun 29; Vol. 6 (2). Date of Electronic Publication: 2020 Jun 29 (Print Publication: 2020).
DOI:	10.1183/23120541.00247-2019
Abstrakt:	Multiple-breath nitrogen washout (MBNW) and its clinical parameter lung clearance index (LCI) are gaining increasing attention for the assessment of small airway function. Measurement of LCI relies on accurate assessment of functional residual capacity (FRC). The EasyOne Pro LAB (ndd) and Exhalyzer D (EM) are two commercially available MBNW devices. The aim of the study was to compare these two devices in vitro and in vivo in healthy subjects with regard to FRC, LCI and secondary outcome parameters and to relate FRC MBNW to FRC measured by body plethysmography (pleth) and helium dilution technique. MBNW measurements were performed using a lung model (FRC between 500 and 4000 mL) in vitro and in 38 subjects aged 6-65 years followed by helium dilution and pleth in vivo using fixed and relaxed breathing techniques. In vitro accuracy within 5% of lung model FRC was 67.3% for ndd, FRC was >5% higher for EM in all tests. In vivo , FRC pleth ranged from 1.2 to 5.6 L. Mean differences (limits of agreement) between FRC pleth and FRC MBNW were -7.0%, (-23.2 to 9.2%) and 5.7% (-11.2 to 22.6%) using ndd and EM, respectively. FRC ndd was consistently lower than FRC EM (-11.8% (-25.6 to 2%)). LCI was comparable between the two devices (-1.3% (-21.9 to 19.3%)). There was a difference of >10 % in LCI in 12 of 38 subjects. Using the most recent software updates, both devices show relevant deviations in FRC measurement both in vitro and in vivo and individual differences in LCI in a significant proportion of subjects. The devices are therefore not interchangeable. Competing Interests: Conflict of interest: A.M. Zwitserloot reports a grant from Stichting Astma Bestrijding and that ndd Medical Technologies provided the EasyOne Pro LAB MBNW device and lung model setup for this study; and money to her institution for an advisory board for GSK outside the submitted work. Conflict of interest: E.J. van den Berg has nothing to disclose. Conflict of interest: L.H.A. Raaijmakers has nothing to disclose. Conflict of interest: W.E. Stalman has nothing to disclose. Conflict of interest: M. van Smaalen has nothing to disclose. Conflict of interest: M. van den Berge reports research grants to his university from GlaxoSmithKline, TEVA, Chiesi and Novartis, outside the submitted work. Conflict of interest: M. Gappa has nothing to disclose. Conflict of interest: G.H. Koppelman reports grants from the Lung Foundation of the Netherlands during the conduct of the study, TETRI Foundation, UBBO EMMIUS Foundation, TEVA the Netherlands, VERTEX and GSK, and that he has participated in an advisory board for GSK, outside the submitted work. Conflict of interest: B.W.M. Willemse has nothing to disclose. (Copyright ©ERS 2020.)
Databáze:	MEDLINE
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