Carboxylic Acid Directed C-H Arylation of Azulene.
| Autor: | Png ZM; Institute of Materials Research and Engineering, the Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore., Tam TLD; Institute of Materials Research and Engineering, the Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore., Xu J; Institute of Materials Research and Engineering, the Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore.; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2020 Jul 02; Vol. 22 (13), pp. 5009-5013. Date of Electronic Publication: 2020 Jun 17. |
| DOI: | 10.1021/acs.orglett.0c01576 |
| Abstrakt: | The first example of directed C-H activation for azulene is reported. A variety of 2-arylazulenes are obtainable exclusively from 1-azulene carboxylic acids, with yields of up to 82%. Some heteroaryl groups such as pyridine and thiophene are also tolerated in the reaction. The efficacy of the reaction is found to be highly dependent on the conditions, with a phosphate base and a bulky carboxylic acid being key additives. |
| Databáze: | MEDLINE |
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