| Autor: |
Viet Cuong LC; Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam.; Graduate University of Science and Technology (VAST), Hanoi, Vietnam., Lien LT; Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam., Minh Phuong NT; Faculty of Environment and Chemical Engineering, Duy Tan University (DTU), Da Nang, Vietnam., Kim Thu VT; Faculty of Food Science and Technology, Thu Dau Mot University, Thu Dau Mot, Vietnam., Phuong Ha T; Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam., Huu Dat TT; Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam., Hai Ha PT; Faculty of Biotechnology, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam., Anh TTP; Graduate University of Science and Technology (VAST), Hanoi, Vietnam., Tuan Anh HL; Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam.; Graduate University of Science and Technology (VAST), Hanoi, Vietnam. |
| Abstrakt: |
A phytochemical investigation of Solanum torvum led to the isolation of eleven steroidal glycosides, including neochlorogenin 6- O - β -D-quinovopyranoside ( 1 ), (22 R ,23 S ,25 R )-3 β -6 α ,23-trihydroxy-5 α -spirostane 6- O - β -D-xylopyranosyl-(1→3)- β -D-quinovopyranoside ( 2 ), neochlorogenin 6- O - α -L-rhamnopyranosyl-(1→3)- β -D-quinovopyranoside ( 3 ), solagenin 6- O - α -L-rhamnopyranosyl-(1→3)- β -D-quinovopyranoside ( 4 ), paniculonin A ( 5 ), paniculonin B ( 6 ), 6α- O -[ β -D-xylopyranosyl-(1→3) β -D-quinovopyranosyl]-(25 S )-5α-spirostan-3 β -ol ( 7 ), torvoside J ( 8 ), torvoside K ( 9 ), torvoside L ( 10 ) and solagenin 6- O - β -D-quinovopyranoside ( 11 ). Their chemical structures were elucidated by 1D-NMR and 2D-NMR data as well as comparison with the data reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against SK-LU-1, HepG2, MCF-7 and T24 cancer cell lines. Among them, compounds 1 , 3 , 7 and 11 exhibited cytotoxicity against all four tested cell lines with IC 50 values ranging from 7.89 ± 0.87 to 46.76 ± 3.88 µM. |
