| Autor: |
Tran TVA; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam., Nguyen VM; Faculty of Food Technology, Nha Trang University, 02 Nguyen Dinh Chieu, Nha Trang 650000, Viet Nam., Nguyen TAN; Department of Chemistry, University of Sciences, Hue University, Hue City 530000, Viet Nam., Nguyen DHT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam., Tran DH; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam., Bui TPT; Faculty of Fundamental Science, Van Lang University, Ho Chi Minh 700000, Viet Nam., Pham VT; Institute of Development and Applied Economics, Hoa Sen University, Ho Chi Minh City 700000, Viet Nam., Nguyen TH; Faculty of Food Technology, Nha Trang University, 02 Nguyen Dinh Chieu, Nha Trang 650000, Viet Nam. |
| Abstrakt: |
Three new compounds (methyl-3 β ,25-dihydroxycycloart-23-en-29-oate 3-sulfate ( 1 ), methyl-3 β -hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate ( 2 ) and 3 β -hydroxy-25-methoxycycloart-23-ene 3-sulfate ( 3 )) and a known one (3 β -hydroxycycloart-24-en-23-one 3-sulfate ( 4 )) were isolated from Vietnamese red alga Tricleocarpa fragilis . All isolated compounds 1 - 4 showed potent inhibitory activity against yeast α-glucosidase with IC 50 values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings.[Formula: see text]. |
