Synaptic Loss in Multiple Sclerosis Spinal Cord.

Autor: Petrova N; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Nutma E; Pathology Department, Amsterdam University Medical Center, HV Amsterdam, The Netherlands., Carassiti D; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Rs Newman J; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Amor S; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Pathology Department, Amsterdam University Medical Center, HV Amsterdam, The Netherlands., Altmann DR; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Baker D; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Schmierer K; The Blizard Institute (Centre for Neuroscience, Surgery, and Trauma), Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Clinical Board Medicine (Neurosciences), The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
Jazyk: angličtina
Zdroj: Annals of neurology [Ann Neurol] 2020 Sep; Vol. 88 (3), pp. 619-625. Date of Electronic Publication: 2020 Jul 16.
DOI: 10.1002/ana.25835
Abstrakt: Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area-a predictor of disability-is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58-96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619-625.
(© 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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