Physical Activity Is Associated With Better Vascular Function in Children and Adolescents With Congenital Heart Disease.

Autor: Lopez JR; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Voss C; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Kuan MTY; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Hemphill NM; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Sandor GGS; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Harris KC; Division of Cardiology, Department of Paediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Electronic address: kharris2@cw.bc.ca.
Jazyk: angličtina
Zdroj: The Canadian journal of cardiology [Can J Cardiol] 2020 Sep; Vol. 36 (9), pp. 1474-1481. Date of Electronic Publication: 2019 Dec 28.
DOI: 10.1016/j.cjca.2019.12.019
Abstrakt: Background: Aortic stiffness is an important marker of cardiovascular risk and is elevated in children and adolescents with congenital heart disease (CHD) compared with healthy children; however, in children with CHD, little is known about the interaction between aortic stiffness and physical activity-a key determinant of aortic stiffness.
Methods: For this cross-sectional cohort study, we recruited children and adolescents aged 9-16 years with moderate-to-complex CHD from British Columbia Children's Hospital and travelling partnership clinics across the province of British Columbia and the Yukon territory. Mean daily minutes of moderate-to-vigorous physical activity were objectively assessed using an ActiGraph accelerometer worn over the right hip during waking hours for 7 days. Aortic pulse wave velocity (cm/s) was measured using standard 2-dimensional echocardiography and Doppler ultrasound.
Results: Participants (n = 104, 61% male; 85% consent rate) had a mean (standard deviation) age of 12.4 (2.4) years. Daily moderate-to-vigorous physical activity was 46.7 (20.0) minutes/d, with 25% meeting guidelines of ≥ 60 minutes of moderate-to-vigorous physical activity per day. Mean (standard deviation) aortic pulse wave velocity was 490.5 (161.9) cm/s, which was not significantly different between cardiac diagnoses. Higher levels of moderate-to-vigorous physical activity were associated with lower aortic pulse wave velocity (r = -0.226, P = 0.021).
Conclusion: In children and adolescents with CHD, higher levels of physical activity are associated with better vascular function. Given this association, promoting physical activity should be a high priority in the care of children and adolescents with CHD.
(Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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