| Autor: |
Zhang CY; Marine College, Shandong University, Weihai 264209, China., Lin SQ; Marine College, Shandong University, Weihai 264209, China., Liu FY; Marine College, Shandong University, Weihai 264209, China., Ma JH; Marine College, Shandong University, Weihai 264209, China., Jia FJ; Marine College, Shandong University, Weihai 264209, China., Han Z; Marine College, Shandong University, Weihai 264209, China., Xie WD; Marine College, Shandong University, Weihai 264209, China., Li X; Marine College, Shandong University, Weihai 264209, China.; School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. |
| Abstrakt: |
Ent -kaur-15-en-17-al-18-oic acid (LL-3) was demonstrated that it can inhibit LPS-induced nitric oxide (NO) production and macrophage migration, maintain homeostasis of oxidative stress, including increased mitochondrial membrane potential (MMP), decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and maintenance of superoxide dismutase (SOD) and glutathione (GSH) activities and inhibit oxidative stress-induced P38 and nuclear factor κB (NF-κB) pathways to decrease inducible nitric oxide synthase (iNOS), cyclooxygense-2 (COX-2), and tumour necrosis factor (TNF)-α mRNA expressions without marked cytotoxicity. These findings revealed that LL-3 could serve as a candidate lead compound for further studying anti-inflammatory therapies.[Formula: see text]. |
