Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells.

Autor: Vaden RJ; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Gonzalez JC; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Tsai MC; Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, United States., Niver AJ; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Fusilier AR; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Griffith CM; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Kramer RH; Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, United States., Wadiche JI; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States., Overstreet-Wadiche L; Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2020 Jun 30; Vol. 9. Date of Electronic Publication: 2020 Jun 30.
DOI: 10.7554/eLife.54125
Abstrakt: Parvalbumin-expressing interneurons (PVs) in the dentate gyrus provide activity-dependent regulation of adult neurogenesis as well as maintain inhibitory control of mature neurons. In mature neurons, PVs evoke GABA A postsynaptic currents (GPSCs) with fast rise and decay phases that allow precise control of spike timing, yet synaptic currents with fast kinetics do not appear in adult-born neurons until several weeks after cell birth. Here we used mouse hippocampal slices to address how PVs signal to newborn neurons prior to the appearance of fast GPSCs. Whereas PV-evoked currents in mature neurons exhibit hallmark fast rise and decay phases, newborn neurons display slow GPSCs with characteristics of spillover signaling. We also unmasked slow spillover currents in mature neurons in the absence of fast GPSCs. Our results suggest that PVs mediate slow spillover signaling in addition to conventional fast synaptic signaling, and that spillover transmission mediates activity-dependent regulation of early events in adult neurogenesis.
Competing Interests: RV, JG, MT, AN, AF, CG, RK, JW No competing interests declared, LO Reviewing editor, eLife
(© 2020, Vaden et al.)
Databáze: MEDLINE
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