Association of Polymorphisms in Cytokine genes with susceptibility to Precancerous Lesions and Cervical Cancer: A systematic review with meta-analysis.

Autor: de Moura EL; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., Dos Santos ACM; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., da Silva DM; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., Dos Santos BB; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., Figueredo DS, Moura AWA; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil., da Silva AF; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil., Tanabe ISB; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., de Lira Tanabe EL; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., Lira Neto AB; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil., Pereira E Silva AC; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil., de Carvalho Fraga CA; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Faculty of Medicine, Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil., de Lima Filho JL; Laboratory Keizo Asami of Immunopathology (LIKA), Federal University of Pernambuco, Recife, Pernambuco, Brazil., de Farias KF; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil., Martins de Souza EV; Laboratory of Molecular Biology and Gene Expression (LABMEG), Federal University of Alagoas (UFAL), Arapiraca, Alagoas, Brazil.; Post-graduation Program in Health Science, Institute of Biological Sciences and Health (ICBS), Federal University of Alagoas (UFAL), Maceió, Alagoas, Brazil.
Jazyk: angličtina
Zdroj: Immunological investigations [Immunol Invest] 2021 Jul; Vol. 50 (5), pp. 492-526. Date of Electronic Publication: 2020 Jun 30.
DOI: 10.1080/08820139.2020.1778023
Abstrakt: Objectives : This study investigated the relationship between single-nucleotide polymorphisms (SNPs) in cytokine genes and the susceptibility to Squamous Intraepithelial Lesions (SIL), cervical cancer and HPV infection through a systematic review with meta-analysis. To verify the effect of SNPs, we also analyzed the transcription factor binding affinity using bioinformatics tools. Methods : Seven electronic databases (MEDLINE, Scielo, BIREME, PubMed, Scopus, Web of Science and Science Direct) were searched for case-control studies. Results : A total of 35 relevant case-control studies were meta-analyzed, including 7 cytokine genes and 15 SNPs. SNPs in IL-17A (rs2275913, rs3748067); IL-17 F (rs763780); IL-12A (rs568408); IL-12B (rs3212227); TNFA (rs1800629, rs361525); IL-1B (rs16944); IL-6 (rs1800795); IL-10 (rs1800896) genes were associated with increased risk for cervical cancer. No association was observed between meta-analyzed polymorphisms and SIL. Additional bioinformatics analysis suggested a possible transcriptional regulation pathway of the TNFA and IL-10 genes through the MZF1 ( TNFA -308 G > A and IL-10  - 1082A>G) and ZNF263 ( TNFA -238 G > A) transcription factors binding. Conclusion : Overall, 10 SNPs in cytokine genes were associated with increased risk for cervical cancer. Therefore, in our meta-analysis, these SNPs demonstrated to be potential biomarkers for predicting or identifying cases of high risk for SIL and cervical cancer.
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje