Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

Autor:	Ahmed OS; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France.; Department of Analytical Chemistry, Faculty of Pharmacy, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of October City, P.O.Box: 77, Egypt., Galano JM; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France., Pavlickova T; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France., Revol-Cavalier J; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France., Vigor C; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France., Lee JC; School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region., Oger C; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France., Durand T; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, France.
Jazyk:	angličtina
Zdroj:	Essays in biochemistry [Essays Biochem] 2020 Sep 23; Vol. 64 (3), pp. 463-484.
DOI:	10.1042/EBC20190096
Abstrakt:	Polyunsaturated fatty acids (PUFAs) are essential components in eukaryotic cell membrane. They take part in the regulation of cell signalling pathways and act as precursors in inflammatory metabolism. Beside these, PUFAs auto-oxidize through free radical initiated mechanism and release key products that have various physiological functions. These products surfaced in the early nineties and were classified as prostaglandin isomers or isoprostanes, neuroprostanes and phytoprostanes. Although these molecules are considered robust biomarkers of oxidative damage in diseases, they also contain biological activities in humans. Conceptual progress in the last 3 years has added more understanding about the importance of these molecules in different fields. In this chapter, a brief overview of the past 30 years and the recent scope of these molecules, including their biological activities, biosynthetic pathways and analytical approaches are discussed. (© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
Databáze:	MEDLINE
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