Health-related quality of life and health utility score of patients with gastric cancer: A multi-centre cross-sectional survey in China.

Autor:	Xia R; Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China., Zeng H; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Liu Q; Xi'an Center for Disease Control and Prevention, Xi'an, China., Liu S; Henan Cancer Hospital, Zhengzhou, China., Zhang Z; Wuwei Cancer Hospital of Gansu Province, Wuwei, China., Liu Y; Gansu Provincial Cancer Hospital, Lanzhou, China., Guo G; Linzhou Cancer Hospital, Linzhou, China., Song G; Cixian Institute for Cancer Prevention and Control, Cixian Cancer Hospital, Handan, China., Zhu Y; Luoshan Center for Disease Control and Prevention, Xinyang, China., Wu X; Center for Disease Control and Prevention of Sheyang County, Yancheng, China., Song B; Tumor Prevention and Treatment Institute, Harbin Medical University, Harbin, China., Liao X; Hunan Provincial Cancer Hospital, Changsha, China., Chen Y; Yueyang Lou District Center for Disease Prevention and Control, Yueyang, China., Wei W; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Chen G; Centre for Health Economics, Monash Business School, Monash University, Melbourne, Vic., Australia., Chen W; National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhuang G; Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Jazyk:	angličtina
Zdroj:	European journal of cancer care [Eur J Cancer Care (Engl)] 2020 Nov; Vol. 29 (6), pp. e13283. Date of Electronic Publication: 2020 Jun 29.
DOI:	10.1111/ecc.13283
Abstrakt:	Objective: To evaluate the health-related quality of life (HRQoL) and health state utility scores of gastric cancer patients in daily life at different clinical stages after treatment, and to explore influencing factors associated with HRQoL. Methods: Gastric cancer patients discharged from hospitals and healthy controls identified by screening were recruited. The three-level EQ-5D was employed to assess HRQoL and was scored using two Chinese-specific tariffs published in 2014 and 2018. Results: A total of 1,399 patients and 2,179 healthy controls were recruited. The likelihood of reporting problems in the five dimensions for patients was 4.0-23.8 times higher than controls. Based on the 2014/2018 tariff, the mean EQ-5D utility score was 0.321/0.163 lower than controls, and the mean utility scores of each patient subgroup were 0.077/0.039 (high-grade intraepithelial neoplasia/carcinoma in situ), 0.254/0.121 (Stage I), 0.249/0.123 (Stage II), 0.353/0.182 (Stage III) and 0.591/0.309 (Stage IV) lower than controls (all statistically significant). Age, occupation, duration of illness, other chronic disease status and therapeutic regimen had a significant impact upon different aspects of HRQoL in patients. Conclusions: Gastric cancer significantly impaired patients' HRQoL in daily life after treatment. More advanced cancer stages were associated with larger decrements on health state utility. (© 2020 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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