Iron imaging in myocardial infarction reperfusion injury.

Autor: Moon BF; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Iyer SK; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hwuang E; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Solomon MP; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Hall AT; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Kumar R; Department of Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Josselyn NJ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Higbee-Dempsey EM; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tsourkas A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Imai A; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Okamoto K; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Saito Y; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pilla JJ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gorman JH 3rd; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gorman RC; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tschabrunn C; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Keeney SJ; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Castillero E; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Ferrari G; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Jockusch S; Department of Chemistry, Columbia University, New York, NY, USA., Wehrli FW; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shou H; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ferrari VA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Han Y; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gulhane A; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Litt H; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Matthai W; Department of Medicine, Penn Presbyterian Medical Center, University of Pennsylvania, Philadelphia, PA, USA., Witschey WR; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. witschey@pennmedicine.upenn.edu.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. witschey@pennmedicine.upenn.edu.; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. witschey@pennmedicine.upenn.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Jun 29; Vol. 11 (1), pp. 3273. Date of Electronic Publication: 2020 Jun 29.
DOI: 10.1038/s41467-020-16923-0
Abstrakt: Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation.
Databáze: MEDLINE