Natural products for orofacial nociception in pre-clinical studies: A systematic review.

Autor: Oliveira JP; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Programme in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil., Souza MTS; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil., Cercato LM; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil., Souza AW; Departament of Pharmacy, Federal University of Paraná, Curitiba, PR, Brazil., Nampo FK; Latin American Institute of Life and Natural Sciences, Federal University of Latin American Integration, Foz do Iguaçu, PR, Brazil., Camargo EA; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil; Graduate Programme in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address: enilton.camargo@pq.cnpq.br.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2020 Sep; Vol. 117, pp. 104748. Date of Electronic Publication: 2020 May 11.
DOI: 10.1016/j.archoralbio.2020.104748
Abstrakt: Objective: The aim of this systematic review was to summarize the use of natural products (NP) in the treatment of orofacial nociception in animal models.
Methods: Pre-clinical studies that have evaluated the efficacy of NPs in experimental orofacial nociception were sought in the Medline, Web of Science, Scopus, Embase, SciELO, LILACS and Scholar databases in January 2020, covering the period since the inception of each one. Two reviewers independently selected the studies, extracted the data and evaluated the risk of bias of the included studies.
Results: We included 41 records in qualitative synthesis. Fifty different NPs were investigated. All studies presented positive results for at least one orofacial nociception test. Regarding the risk of bias, most studies presented poor experimental design, mainly lack of randomization and blinding. The main class of isolated compounds tested was terpenes, of which monoterpenes were investigated in the majority of the studies.
Conclusion: These results indicate that NPs are effective in treating experimental orofacial nociception and highlight some of these NPs, mainly terpenes, suggesting their potential for translational research.
Competing Interests: Declaration of Competing Interest No conflict of interest to be declared.
(Copyright © 2020. Published by Elsevier Ltd.)
Databáze: MEDLINE
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