Chitosan biomaterials application in dentistry.

Autor: Fakhri E; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Eslami H; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Maroufi P; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Pakdel F; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Taghizadeh S; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Ganbarov K; Department of Microbiology, Baku State University, Baku, Azerbaijan., Yousefi M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Tanomand A; Department of Microbiology, Maragheh University of Medical Sciences, Maragheh, Iran., Yousefi B; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Mahmoudi S; Student's Affair Organization, University of Tabriz, Tabriz, Iran., Kafil HS; Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Kafilhs@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 956-974. Date of Electronic Publication: 2020 Jun 26.
DOI: 10.1016/j.ijbiomac.2020.06.211
Abstrakt: Chitosan is a natural biopolymer derived from deacetylation of chitin and it has been investigated with interdisciplinary approaches for multitude applications. Chitosan biomaterials possess unique properties such as biocompatibility, biodegradability, non-toxicity, muco-adhesion and a wide range of antibacterial and antifungal activity. Additionally, chitosan is the only cationic polysaccharide in nature and can be chemically modified to derivatives, based on the aim of function and application. The distinctive properties of chitosan and its derivatives have aroused interest in pharmaceutical industries and biomedical fields worldwide. This review discusses the crucial role of chitosan in production of bio-dental materials and accentuates its current profitable utilizations in oral drug delivery system, bone tissue engineering for treatment of periodontitis and dentin-pulp regeneration. Chemical modifications and incorporation of diverse bioactive molecules in order to improve the mechanical and biological characteristics of chitosan have also been discussed.
Competing Interests: Declaration of competing interest None to declare.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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