| Autor: |
Vasilyev VI; Nasonova Research Institute of Rheumatology., Palshina SG; Nasonova Research Institute of Rheumatology., Pavlovskaya AI; Blokhin National Medical Research Center of Oncology., Kokosadze NV; Blokhin National Medical Research Center of Oncology., Chaltsev BD; Nasonova Research Institute of Rheumatology., Shornikova LA; Yevdokimov Moscow State University of Medicine and Dentistry. |
| Jazyk: |
ruština |
| Zdroj: |
Terapevticheskii arkhiv [Ter Arkh] 2020 Jun 05; Vol. 92 (5), pp. 78-84. Date of Electronic Publication: 2020 Jun 05. |
| DOI: |
10.26442/00403660.2020.05.000440 |
| Abstrakt: |
Idiopathic multicentric Castlemans disease is a rare lymphoproliferative disorder that has many similar laboratory, radiological, clinical and pathological manifestations with various conditions, including IgG4-related disease. Increased activity of cytokines, especially interleukin-6, leads to systemic inflammatory symptoms with the development of lymphadenopathy and rarely extranodal lesions. Histological changes in the lymph nodesin hyaline vascular and plasma cell variants of Castlemans disease are hardly distinguishable from the pattern of reactive, tumor and IgG4-related lymphadenopathy. Idiopathic multicentric Castlemans disease can be diagnosed only when infection with human herpesvirus-8 type and human immunodeficiency virus is excluded. In the article, the authors describe two cases of idiopathic multicentric Castlemans disease, including the first world literature description of extranodal damage of the hip muscle in this disorder. In addition, the authors gave a review of the literature on the main clinical, laboratory and morphological manifestations, which allow confirming the diagnosis of Castlemans disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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