Clinical and cytopathological characteristics of HTLV-1 + hodgkin lymphoma.

Autor: Kobata K; Division of Diagnostic Pathology, Faculty of Medicine, Fukuoka University Hospital, Fukuoka, Japan., Kimura S; Departments of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Mihashi Y; Departments of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.; Departments of Otolaryngology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Iwasaki H; Departments of Hematology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan., Nonaka S; Departments of Pathology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan., Matsumoto S; Division of Diagnostic Pathology, Faculty of Medicine, Fukuoka University Hospital, Fukuoka, Japan., Takamatsu Y; Division of Medical Oncology, Hematology and Infectious Diseases, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Choi I; Department of Hematology, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan., Kawauchi S; Departments of Pathology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan., Ishitsuka K; Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan., Takeshita M; Division of Diagnostic Pathology, Faculty of Medicine, Fukuoka University Hospital, Fukuoka, Japan.; Departments of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2020 Aug; Vol. 9 (16), pp. 5788-5797. Date of Electronic Publication: 2020 Jun 28.
DOI: 10.1002/cam4.3139
Abstrakt: Background: Human T-lymphotropic virus-1 (HTLV-1) + Hodgkin lymphoma (HL) is difficult to differentiate from adult T-cell leukemia/lymphoma (ATLL) with HL-like histology (HL-like ATLL).
Methods: Cytological and immunohistological features, HTLV-1 proviral DNA integration, and rearrangements of the T-cell receptor (TCR) Cβ1 gene were examined in 11 HTLV-1 + patients with HL-like disease.
Results: Six patients were classified as HTLV-1 + HL and five as HL-like ATLL in accordance with genetic findings of HTLV-1 proviral DNA integration and rearrangements of the TCR Cβ1 gene. Small ordinary looking lymphocytes with round nuclei were detected in the background of six patients with HTLV-1 + HL, which were immunohistochemically negative for CD25 and CC chemokine receptor (CCR)4 and had a low MIB1 labeling index (mean: 28.3%). In the HL-like ATLL specimens, small- and medium-sized atypical lymphocytes with indented and irregular-shaped nuclei were found, and were diffusely positive for CD25 and CCR4, with high MIB1 labeling (mean: 76%). Both groups had scattered CD30 + and CD15 + Hodgkin and Reed Sternberg (RS) giant cells, with or without CD20 expression and Epstein-Barr virus infection. The 50% overall survival period was significantly longer for the HTLV-1 + HL group (180 months) than for the HL-like ATLL group (7.8 months; P = .004).
Conclusions: HTLV-1 + HL showed typical small lymphoid cells with a low MIB1 labeling index in a background of Hodgkin and RS cells, with some scattered CD25 + and CCR4 + lymphocytes. In HTLV-1 endemic areas, distinguishing HTLV-1 + HL from HL-like ATLL is important because of their differing treatment strategies and prognoses.
(© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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