Ursolic acid has no additional effect on muscle strength and mass in active men undergoing a high-protein diet and resistance training: A double-blind and placebo-controlled trial.

Autor: Lobo PCB; Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, Brazil., Vieira IP; Faculty of Physical Education and Dance, Federal University of Goias, Goiânia, Brazil., Pichard C; Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland., Marques BS; Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Gentil P; Faculty of Physical Education and Dance, Federal University of Goias, Goiânia, Brazil., da Silva EL; Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil; Post-Graduation Program in Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Pimentel GD; Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, Brazil. Electronic address: gupimentel@yahoo.com.br.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 Feb; Vol. 40 (2), pp. 581-589. Date of Electronic Publication: 2020 Jun 13.
DOI: 10.1016/j.clnu.2020.06.004
Abstrakt: Background: Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This study sought to compare the effects of UA and a placebo on muscle strength and mass in young men undergoing resistance training (RT) and consuming a high-protein diet.
Methods: A clinical, double-blind, placebo-controlled trial was conducted for 8 weeks. The Control + RT group (CON n = 12) received 400 mg/d of placebo, and the UA + RT group (UA n = 10) received 400 mg/d of UA. Both groups ingested ~1.6 g/kg of protein and performed the same RT program. Pre- and post-intervention, both groups were evaluated for anthropometric measures, body composition, food intake and muscle strength.
Results: Food intake remained unchanged throughout the study. Both groups showed significant increases in body weight (CON Δ: 2.12 ± 0.47 kg, p = 0.001 vs. UA Δ: 2.24 ± 0.67 kg, p = 0.009), body mass index (BMI) (CON Δ: 0.69 ± 0.15 kg/m 2 , p = 0.001 vs. UA Δ: 0.75 ± 0.23, p = 0.011) and thigh circumference (CON Δ: 1.50 ± 0.36, p = 0.002 vs. UA Δ: 2.46 ± 0.50 cm, p = 0.003 vs. UA 1.84 ± 0.82 cm, p = 0.001), with differences between them. There was no difference in the arm, waist and hip circumferences. Both groups showed increases in muscle mass (CON Δ: 1.12 ± 0.26, p = 0.001 vs. UA Δ: 1.08 ± 0.28 kg, p = 0.004), but there was no significant difference between them. Additionally, there were significant increases in the one repetition maximum test in the bench press and in the 10-repetition maximum test in the knee extension (CON Δ: 5.00 ± 2.09, p = 0.036 vs. UA Δ: 7.8 ± 1.87, p = 0.340 and CON Δ: 3.58 ± 1.15, p = 0.010 vs. UA Δ: 1.20 ± 0.72, p = 0.133), respectively, with no difference between them.
Conclusions: Ursolic acid had no synergic effect on muscle strength and mass in response to RT in physically active men consuming a high-protein diet.
Brazilian Clinical Trials Registry (rebec): RBR-76tbqs.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
(Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
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