Rate of BCG Immunization in HIV-Exposed Infants in a Selected Primary Health Centre in Southern Nigeria: Implications of No Vaccine Policy for HIV-Positive Infants.

Autor:	Ekanem AM; Department of Community Health, Faculty of Clinical Sciences, University of Uyo/University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria 520271., Oloyede IP; Department of Paediatrics, University of Uyo/University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria 520271., Ekrikpo UE; Department of Internal Medicine, University of Uyo/University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria 520271., Idung AU; Department of Family Medicine, University of Uyo/University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria 520271., Edward E; Department of Community Health, University of Uyo Teaching Hospital, Uyo, Akwa Ibom state, Nigeria 520261.
Jazyk:	angličtina
Zdroj:	Journal of tropical pediatrics [J Trop Pediatr] 2021 Jul 02; Vol. 67 (3).
DOI:	10.1093/tropej/fmaa030
Abstrakt:	Background: Maternal and infant HIV status influences the decision of BCG immunization of infants at birth. The objective of this study was to determine the HIV status of HIV-exposed infants (HEIs) by the first HIV DNA PCR test and the rate of BCG uptake among the HEIs who were confirmed HIV negative. Methods: This was a retrospective descriptive cross-sectional study involving the review of results of 99 dried blood samples (DBS) for the first HIV DNA PCR test of HEIs whose mothers were diagnosed HIV positive on presentation of the infants at first immunization visit at a Primary Health Centre from January 2018 to January 2019. Results: Of the 99 DBS examined, 86; 86.9% (95% CI 80.1-93.6) were HIV negative, 9; 9.1% (95% CI 3.3-14.8) were positive while the results of 4 (4.0%) infants were not in the register. Only 7; 7.1% (95% CI 1.9-12.2) of the 99 HEIs returned for BCG immunization at the centre. BCG immunization status of the HEIs after first PCR results was not significantly associated with sex of the infants or availability of phone number of the guardians (p = 0.70 and 0.12, respectively). Conclusion: The majority of HEIs were HIV negative at first HIV DNA PCR test. Few of these HIV negative infants returned for BCG immunization. Hence, all HEIs should be given BCG immunization according to WHO GAVCS committee recommendation on BCG immunization for settings with poor HIV diagnostic and treatment facilities for mothers and infants. (© The Author(s) [2020]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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