A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon.

Autor: Matthewman J; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, & I Dep. of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Manego RZ; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, & I Dep. of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dimessa Mbadinga LB; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Šinkovec H; Center for Medical Statistics, Informatics and Intelligent Systems, Institute of Clinical Biometrics, Medical University of Vienna, Vienna, Austria., Völker K; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, & I Dep. of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Akinosho M; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Haedrich C; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Tardif d'Hamonville J; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon., Lell B; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria., Adegnika AA; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Ramharter M; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, & I Dep. of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, & I Dep. of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jun 26; Vol. 14 (6), pp. e0008423. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
DOI: 10.1371/journal.pntd.0008423
Abstrakt: Background: It is unclear whether individual treatment of scabies is similarly effective compared to household treatment. This study compared these two treatment strategies with topical benzyl benzoate for treating scabies in Lambaréné, Gabon.
Methods: Participants presenting with uncomplicated scabies were randomized into either the Individual Treatment group, where only the affected participants received treatment, or the Household Treatment group, where all family members were treated in parallel to the affected participants regardless of signs and symptoms. The primary endpoint was clinical cure after 28 days; the secondary endpoint was the proportion of affected household members per household after 28 days.
Results: After 28 days, from a total of 79 participants assessed, 67% (n = 53) were clinically cured; 59% (20/34) in the Individual Treatment group and 73% (33/45) in the Household Treatment group. Participants in the Household Treatment group had about twice the odds of being cured (odds ratio 1.9, 95% confidence interval: 0.8-4.9; p = 0.17). For the secondary outcome, an effect of similar size was observed.
Conclusions: Our findings show that treating close contacts of persons affected by scabies may be beneficial to patients and contacts, however, the benefit was less pronounced than anticipated and further research is needed to definitively answer this question.
Competing Interests: The authors report no potential conflicts of interest.
Databáze: MEDLINE
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