Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019.

Autor: Sun JK; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Zhang WH; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Zou L; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Liu Y; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Li JJ; Department of Intensive Care Unit, Lishui People's Hospital, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Kan XH; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Dai L; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Shi QK; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Yuan ST; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Yu WK; Department of Intensive Care Unit, Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Xu HY; Department of Intensive Care Unit, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Gu W; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China., Qi JW; Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.; Department of Isolation Units, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Jiangsu Province, China.
Jazyk: angličtina
Zdroj: Aging [Aging (Albany NY)] 2020 Jun 25; Vol. 12 (12), pp. 11287-11295. Date of Electronic Publication: 2020 Jun 25.
DOI: 10.18632/aging.103526
Abstrakt: The aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. The clinical outcome variables were also recorded. From February 10 to February 28, 2020, 241 patients were enrolled. Of these patients, 180 (74.7%) had hypocalcemia on admission. The median serum calcium levels were 2.12 (IQR, 2.04-2.20) mmol/L, median parathyroid hormone (PTH) levels were 55.27 (IQR, 42.73-73.15) pg/mL, and median 25-hydroxy-vitamin D (VD) levels were 10.20 (IQR, 8.20-12.65) ng/mL. The serum calcium levels were significantly positively correlated with VD levels ( P =0.004) but negatively correlated with PTH levels ( P =0.048). Patients with lower serum calcium levels (especially ≤2.0 mmol/L) had worse clinical parameters, higher incidences of organ injury and septic shock, and higher 28-day mortality. The areas under the receiver operating characteristic curves of multiple organ dysfunction syndrome, septic shock, and 28-day mortality were 0.923 ( P <0.001), 0.905 ( P =0.001), and 0.929 ( P <0.001), respectively. In conclusion, serum calcium was associated with the clinical severity and prognosis of patients with COVID-19. Hypocalcemia may be associated with imbalanced VD and PTH levels.
Databáze: MEDLINE