Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.

Autor: Kuzmin E; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., VanderSluis B; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Nguyen Ba AN; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Center for Analysis of Evolution and Function, University of Toronto, Toronto, Ontario, Canada., Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Koch EN; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Usaj M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Khmelinskii A; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Usaj MM; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., van Leeuwen J; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Kraus O; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Tresenrider A; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Pryszlak M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Hu MC; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Varriano B; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Costanzo M; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Knop M; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Moses A; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Center for Analysis of Evolution and Function, University of Toronto, Toronto, Ontario, Canada.; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada., Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA. charlie.boone@utoronto.ca brenda.andrews@utoronto.ca chadm@umn.edu., Andrews BJ; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. charlie.boone@utoronto.ca brenda.andrews@utoronto.ca chadm@umn.edu.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Boone C; Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada. charlie.boone@utoronto.ca brenda.andrews@utoronto.ca chadm@umn.edu.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2020 Jun 26; Vol. 368 (6498).
DOI: 10.1126/science.aaz5667
Abstrakt: Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: a more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
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