What We Learned about COVID-19 So Far? Notes from Underground.

Autor:	Akyıl FT; Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey., Karadoğan D; Department of Chest Diseases, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey., Gürkan CG; Department of Chest Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey., Yüksel A; Department of Chest Diseases, Ufuk University, School of Medicine, Ankara, Turkey., Arıkan H; Internal Medicine Intensive Care Unit, Yüzüncü Yıl University, Dursun Odabas Medical Center, Van, Turkey., Eyüboğlu TŞ; Department of Pediatric Pulmonology, Gazi University School of Medicine, Ankara, Turkey., Emiralioğlu N; Department of Pediatric Pulmonology, Hacettepe University School of Medicine, Ankara, Turkey., Gürsoy TR; Department of Pediatric Pulmonology, Gazi University School of Medicine, Ankara, Turkey., Şerifoğlu İ; Department of Chest Diseases, Kırıkhan State Hospital, Hatay, Turkey., Töreyin ZN; Department of Occupational Health and Diseases, Adana City Research and Training Hospital, Adana, Turkey., Marim F; Department of Chest Diseases, Kütahya University of Health Sciences, School of Medicine, Kütahya, Turkey., Kara BY; Department of Chest Diseases, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey., Özakıncı H; Department of Pathology, Ankara University School of Medicine, Ankara, Turkey., Develi E; Department of Physiotherapy and Rehabilitation, Yeditepe University Faculty of Health Sciences, İstanbul, Turkey., Çakmakçı S; Department of Chest Diseases, Dokuz Eylül University School of Medicine, İzmir, Turkey., Küsbeci TÇ; Department of Chest Diseases, Yozgat City Hospital, Yozgat, Turkey., Karcıoğlu O; Department of Chest Diseases, Çubuk Halil Sivgin State Hospital, Ankara, Turkey., Gülhan PY; Department of Chest Diseases, Düzce University School of Medicine, Düzce, Turkey., Erçelik M; Department of Chest Diseases, Düzce University School of Medicine, Düzce, Turkey., Er B; Internal Medicine Intensive Care Unit, Hacettepe University School of Medicine, Ankara, Turkey., Ataoğlu Ö; Department of Chest Diseases, Düzce University School of Medicine, Düzce, Turkey., Polat D; Department of Chest Diseases, Mersin University School of Medicine, Mersin, Turkey., Kaya İ; Department of Chest Diseases, Ardahan State Hospital, Ardahan, Turkey., Önyılmaz TA; Department of Chest Diseases, Konak Hospital, İzmir, Turkey., Aydın A; Department of Chest Diseases, Kestel State Hospital, Bursa, Turkey., Kızılırmak D; Department of Chest Diseases, Manisa Celal Bayar University School of Medicine, Manisa, Turkey., Er AB; Department of Chest Diseases, Denizli State Hospital, Denizli, Turkey., Kılınç M; Intensive Care Unit, Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey., Günaydın FE; Department of Allergy and Immunology, Uludağ University School of Medicine, Bursa, Turkey., Gürz S; Department of Thoracic Surgery, Ondokuz Mayıs University School of Medicine, Samsun, Turkey., Karaoğlanoğlu S; Department of Chest Diseases, Ordu University School of Medicine, Ordu, Turkey., Çelik S; Department of Nursing, Yeditepe University Faculty of Health Sciences, İstanbul, Turkey., Esendağlı D; Department of Chest Diseases, Baskent University School of Medicine, Ankara, Turkey., Toptay H; Intensive Care Unit, Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey., Sertçelik ÜÖ; Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey., Akgün M; Department of Chest Diseases, Ataturk University School of Medicine, Erzurum, Turkey.
Jazyk:	angličtina
Zdroj:	Turkish thoracic journal [Turk Thorac J] 2020 May; Vol. 21 (3), pp. 185-192.
DOI:	10.5152/TurkThoracJ.2020.20052
Abstrakt:	The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF