Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network.

Autor: Vu MN; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, 3000, Australia.; Department of Pharmaceutics, Hanoi University of Pharmacy, Hanoi, 10000, Vietnam., Kelly HG; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, 3000, Australia., Wheatley AK; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, 3000, Australia., Peng S; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Pilkington EH; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, 3000, Australia., Veldhuis NA; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Davis TP; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australia Institute of Bioengineering & Nanotechnology, University of Queensland, Brisbane, QLD, 4072, Australia., Kent SJ; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, 3000, Australia.; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Truong NP; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC, 3052, Australia.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2020 Aug; Vol. 16 (33), pp. e2002861. Date of Electronic Publication: 2020 Jun 25.
DOI: 10.1002/smll.202002861
Abstrakt: A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation time and to enhance interactions with targeted cells. During circulation and depending on the selected application (e.g., cancer drug delivery or immune modulators), nanoparticles are required to possess low or high interactions with cells in human blood and blood vessels to minimize side effects or maximize delivery efficiency. However, analysis of cellular interactions in blood vessels is challenging and is not yet realized due to the diverse components of human blood and hemodynamic flow in blood vessels. Here, the first comprehensive method to analyze cellular interactions of both synthetic and commercially available nanoparticles under human blood flow conditions in a microvascular network is developed. Importantly, this method allows to unravel the complex interplay of size, charge, and type of nanoparticles on their cellular associations under the dynamic flow of human blood. This method offers a unique platform to study complex interactions of any type of nanoparticles in human blood flow conditions and serves as a useful guideline for the rational design of liposomes and polymer nanoparticles for diverse applications in nanomedicine.
(© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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