The effects of CYP2C9 and VKORC1 gene polymorphisms on warfarin maintenance dose in Turkish cardiac patients.
| Autor: | Akdeniz CS; Department of Cardiology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey., Cevik M; Department of Molecular Biology, Marmara University Faculty of Science & Letters, Istanbul, Turkey., Canbolat IP; Department of Cardiology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey., Yurdakul S; Department of Cardiology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey., Cagatay P; Vocational School of Health Service, Department of Medical Services & Technics, Istanbul University - Cerrahpasa, Istanbul, Turkey., Ciftci C; Department of Cardiology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey., Karaalp A; Department of Medical Pharmacology, Marmara University School of Medicine, Istanbul, Turkey., Susleyici B; Department of Molecular Biology, Marmara University Faculty of Science & Letters, Istanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Future cardiology [Future Cardiol] 2020 Nov; Vol. 16 (6), pp. 645-654. Date of Electronic Publication: 2020 Jun 25. |
| DOI: | 10.2217/fca-2020-0027 |
| Abstrakt: | Aim: Our aim was to examine the effect of CYP2C9 and VKORC1 polymorphisms on warfarin dose requirements in Turkish patients. Materials & methods: 24 warfarin prescribed patients were included and analyzed for eight VKORC1 and 6 CYP2C9 polymorphisms in the study. Results: Patients with CYP2C9 *1/*1 and VKORC1 -1639 GG and GA genotypes required higher warfarin doses in comparison to wild type VKORC1 genotype. Patients with CYP2C9 *1/*3 and VKORC1 -1639 GG genotypes simultaneously, required the lowest dose of warfarin (4.64 mg/day). Patients with CYP2C9 *1/*1 and VKORC1 9041 AA genotype were found to require higher warfarin doses. Conclusion: Our results provide additional evidence to support the hypothesis that CYP2C9 *2, *3, VKORC1 9041 G > A polymorphisms explain considerable proportion of inter-individual variability in warfarin dose requirement. |
| Databáze: | MEDLINE |
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