Evaluation of safety and efficacy of autologous topical platelet gel vs platelet rich plasma injection in the treatment of venous leg ulcers: A randomized case control study.

Autor: Elgarhy LH; Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt.; Faculty of Medicine, Department of Pathology, Tanta University, Tanta, Egypt., El-Ashmawy AA; Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt.; Faculty of Medicine, Department of Pathology, Tanta University, Tanta, Egypt., Bedeer AE; Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt.; Faculty of Medicine, Department of Pathology, Tanta University, Tanta, Egypt., Al-Bahnasy AM; Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt.; Faculty of Medicine, Department of Pathology, Tanta University, Tanta, Egypt.
Jazyk: angličtina
Zdroj: Dermatologic therapy [Dermatol Ther] 2020 Nov; Vol. 33 (6), pp. e13897. Date of Electronic Publication: 2020 Jul 15.
DOI: 10.1111/dth.13897
Abstrakt: Various management options were tried for Chronic venous leg ulcers (VLUs) with no satisfactory results. Platelet-rich plasma (PRP) is promising in enhancing chronic wound healing by releasing various growth factors. We evaluated the safety and efficacy of topical platelet gel (PG) vs PRP injection in treatment of venous leg ulcers. 20 patients were treated with topical PG (group I), 20 patients received PRP injection (group II), and 20 patients were treated with saline dressing and compression as controls (group III) weekly for 6 weeks. Ulcer improvement was evaluated by pressure ulcer scale for healing (PUSH). Histopathological evaluation and immunohistochemical staining using anti-CD34 were performed before and after treatment. There was significant improvement in PUSH score in group (I) and (II) compared to group (III; P value: .001). However, there was no statistically significant difference in improvement between group I and II (P value = .83). However, topical PG was more effective in diabetics and PRP was more effective in long standing fibrosed ulcers. Histopathology showed reduction of the inflammatory cells infiltrates and well-formed granulation tissue with no difference in immunostaining. So, both topical PG and PRP injection were effective, low cost, and safe procedures in enhancing healing of chronic VLUs.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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