Age-related differences in vitamin D status in Polish centenarians compared with 65-year-olds.

Autor:	Kupisz-Urbańska M; Department of Geriatric Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland. gosia.kupisz.urbanska@gmail.com, Broczek K; Department of Geriatrics, Medical University of Warsaw, Warsaw, Poland, Galus K; Department of Geriatrics, Medical University of Warsaw, Warsaw, Poland, Mossakowska M; International Institute of Molecular and Cell Biology, Warsaw, Poland, Marcinowska-Suchowierska E; Department of Geriatric Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland
Jazyk:	angličtina
Zdroj:	Polish archives of internal medicine [Pol Arch Intern Med] 2020 Oct 29; Vol. 130 (10), pp. 853-859. Date of Electronic Publication: 2020 Jun 24.
DOI:	10.20452/pamw.15460
Abstrakt:	Introduction: Vitamin D status is known to change with age. However, little is known about vitamin D status in centenarians. Objectives: The aim of the study was to assess vitamin D status and correlations among the levels of parathyroid hormone (PTH), 25‑hydroxycholecalciferol (25[OH]D), 1,25-dihydroxycholecalciferol (1,25[OH]D), calcium, inorganic phosphorus, and alkaline phosphatase (ALP) activity in centenarians. Patients and Methods: The study group included 97 participants: 81 women and 16 men (median [interquartile range [IQR]) age, 101.4 [100.5-102.16] years). Centenarians were visited at their homes where examinations were conducted and blood samples collected. The control group consisted of 57 elderly subjects: 35 women and 22 men (median [IQR] age, 65.9 [65.3-66.5] years). The concentrations of PTH, 25(OH)D, and 1,25(OH)D were measured in frozen plasma samples, and calcium, phosphorus, and ALP levels, in serum samples. Results: The median calcium level was 8.88 mg/dl in centenarians versus 9.52 mg/dl in 65‑year-old subjects (P <0.01); ALP, 223 IU versus 190 IU (P = 0.01); phosphorus, 3.01 mg/dl versus 3.23 mg/dl (P = 0.13); PTH, 45.59 pg/ml versus 29.27 pg/ml (P <0.01); 25(OH)D, 7.39 ng/ml versus 19.81 ng/ml (P <0.01); 1,25(OH)D, 57.5 pmol/l versus 78.6 pmol/l (P <0.01). Only centenarians demonstrated correlations among the measured laboratory parameters. Conclusions: Considering lower 25(OH)D, 1,25(OH)D, and calcium concentrations in the majority of centenarians, as well as the negative correlation between vitamin D active metabolites and PTH, vitamin D and calcium should be systematically supplemented in the oldest of the elderly.
Databáze:	MEDLINE
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