| Autor: |
Stoppacher S; Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Graz, Austria., Scheruebel S; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Biophysics, Medical University of Graz, Graz, Austria., Üçal M; Department of Neurosurgery, Medical University of Graz, Graz, Austria., Kornmüller K; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Biophysics, Medical University of Graz, Graz, Austria., Głowacki E; Laboratory of Organic Electronics, Linköping University, Linköping, Sweden., Schindl R; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Biophysics, Medical University of Graz, Graz, Austria., Shrestha N; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Biophysics, Medical University of Graz, Graz, Austria., Schmidt T; Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Biophysics, Medical University of Graz, Graz, Austria., Baumgartner C; Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Graz, Austria., Rienmüller T; Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Graz, Austria. |
| Abstrakt: |
Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation. |
