Two case reports of neuroinvasive West Nile virus infection in the Almaty region, Kazakhstan.

Autor:	Ostapchuk YO; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Zhigailov AV; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Perfilyeva YV; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Shumilina AG; Tekeli City Hospital, Tekeli, 25 Tauelsizdik Str., Tekeli, 041700, Kazakhstan., Yeraliyeva LT; National Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, 5 Bekhozhina Str., Almaty, 050010, Kazakhstan., Nizkorodova AS; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Kuznetsova TV; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Iskakova FA; Al-Farabi Kazakh National University, Department of Epidemiology, Biostatistics and Evidence-based Medicine, 71 Al-Farabi Str., Almaty, 050040, Kazakhstan., Berdygulova ZA; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Neupokoyeva AS; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Mamadaliyev SM; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan., Dmitrovskiy AM; Almaty Branch of National Center for Biotechnology, 14g Zhahanger Str., Almaty, 050054, Kazakhstan.
Jazyk:	angličtina
Zdroj:	IDCases [IDCases] 2020 Jun 15; Vol. 21, pp. e00872. Date of Electronic Publication: 2020 Jun 15 (Print Publication: 2020).
DOI:	10.1016/j.idcr.2020.e00872
Abstrakt:	Background: West Nile virus (WNV) is a member of the genus Flavivirus , which transmitted to humans mainly by mosquitoes. Recent pilot serosurveillance data from the Almaty region, Kazakhstan, suggest widespread WNV circulation in this area. This report includes two cases of neuroinvasive WNV infection in the same family living in a rural area near Tekeli city, Eskeldinsky district, Almaty region, Kazakhstan. Occurring concurrently and manifesting as WNV infection with febrile illness and symptoms of meningoencephalitis. Methods: The study performed retrospective analysis of clinical histories and achieved serum samples obtained from patients with febrile and meningoencephalitic syndromes of unknown origin in the Almaty region spanning from April 1 to October 31, 2019. All sera samples obtained from patients with clinically suspected cases of acute WNV infection were retrospectively tested for WNV and tick-borne encephalitis virus by commercial immunoassays. Two cases were selected. Cases Presentation: We report two cases that occurred in August 2019 in a rural area near Tekeli city. Previously healthy 28- and 19-year-old husband and wife with febrile illness and neurological manifestations were hospitalized with the diagnosis of meningoencephalitis of unknown etiology and treated empirically. Retrospective serological analysis showed the presence of high titers of IgG against WNV on day 9 after onset of symptoms in cases. Conclusions: This is the first report of aseptic meningitis with WNV infection in the background in Kazakhstan. The obtained data suggest circulation of WNV in the Almaty region and emphasize importance of laboratory testing for WNV in suspicious cases occurring in the region. Competing Interests: The authors declare that they have no conflicts of interest. (© 2020 The Author(s).)
Databáze:	MEDLINE
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