| Autor: |
Aljaibeji H; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE., Mohammed AK; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE., Alkayyali S; Laboratory of Clinical Chemistry and Transfusion Medicine, Central Hospital of Växjö, Växjö 35188, Sweden., Hachim MY; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, UAE., Hasswan H; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE., El-Huneidi W; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE., Taneera J; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE., Sulaiman N; Department of Family Medicine, College of Medicine, University of Sharjah, Sharjah 27272, UAE.; Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia. |
| Abstrakt: |
Phosphatidylinositol-specific phospholipase C X domain 3 (PLCXD3) has been shown to influence pancreatic β-cell function by disrupting insulin signaling. Herein, we investigated two genetic variants in the PLCXD3 gene in relation to type 2 diabetes (T2D) or metabolic syndrome (MetS) in the Emirati population. In total, 556 adult Emirati individuals (306 T2D and 256 controls) were genotyped for two PLCXD3 variants (rs319013 and rs9292806) using TaqMan genotyping assays. The frequency distribution of minor homozygous CC genotype of rs9292806 and GG genotype of rs319013 were significantly higher in subjects with MetS compared to Non-MetS ( p < 0.01). The minor homozygous rs9292806-CC and rs319013-GG genotypes were significantly associated with increased risk of MetS (adj. OR 2.92; 95% CI 1.61-5.3; p < 0.001) (adj. OR 2.62; 95% CI 1.42-4.83; p = 0.002), respectively. However, no associations were detected with T2D. In healthy participants, the homozygous minor genotypes of both rs9292806 and rs319013 were significantly higher fasting glucose (adj. p < 0.005), HbA1c (adj. p < 0.005) and lower HDL-cholesterol (adj. p < 0.05) levels. Data from T2D Knowledge Portal database disclosed a nominal association of rs319013 and rs9292806 with T2D and components of MetS. Bioinformatics prediction analysis showed a deleterious effect of rs9292806 on the regulatory regions of PLCXD3 . In conclusion, this study identifies rs319013 and rs9292806 variants of PLCXD3 as additional risk factors for MetS in the Emirati population. |
