A durable complete response to immunotherapy in a patient with metastatic alveolar soft part sarcoma.
| Autor: | Mariuk-Jarema A; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Koseła-Paterczyk H; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Rogala P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Klimczak A; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Wągrodzki M; Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Maksymiuk B; Department of Pathology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. |
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| Jazyk: | angličtina |
| Zdroj: | Tumori [Tumori] 2020 Dec; Vol. 106 (6), pp. NP9-NP13. Date of Electronic Publication: 2020 Jun 22. |
| DOI: | 10.1177/0300891620928133 |
| Abstrakt: | Background: Recent years have brought the dynamic development of a new method of cancer treatment: immunotherapy. Monoclonal antibodies blocking the programmed death receptor 1 (PD-1) are now widely used in the treatment of several malignancies: melanoma, lung, head and neck cancer, among others. The therapeutic benefit of immunotherapy in soft tissue sarcoma (STS) has not yet been proven. The exception is results obtained in the treatment of a rare STS subtype alveolar soft part sarcoma (ASPS). Case Report: We describe a case of a man with a diagnosis of metastatic ASPS in whom the use of immunotherapy with nivolumab resulted in excellent long-term clinical benefit and a pathologically confirmed complete response. Conclusion: There are strong indications that immunotherapy may become the next important treatment method of ASPS. |
| Databáze: | MEDLINE |
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