Novel SARS-CoV-2/COVID-19: Origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis.

Autor: Junejo Y; Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan., Ozaslan M; Department of Biology, Division of Molecular Biology and Genetics, Gaziantep University, 27310 Gaziantep, Turkey., Safdar M; Department of Biology, Division of Molecular Biology and Genetics, Gaziantep University, 27310 Gaziantep, Turkey.; Department of Breeding and Genetics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan., Khailany RA; Department of Biology, College of Science, Salahaddin University-Erbil, Iraq.; Department of Biology, Faculty of Education, Tishk International University, Erbil, Iraq., Rehman S; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources of Guangxi University, Nanning 530005, China., Yousaf W; Institute of Animal and Dairy Sciences, Faculty of Animal Husbandry, University of Agriculture, Faisalabad, Pakistan., Khan MA; Department of Breeding and Genetics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
Jazyk: angličtina
Zdroj: Gene reports [Gene Rep] 2020 Sep; Vol. 20, pp. 100752. Date of Electronic Publication: 2020 Jun 15.
DOI: 10.1016/j.genrep.2020.100752
Abstrakt: In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for developing broadly effective preventions and vaccines to cope COVID-19. Towards the end of 2019, SARS-CoV-2 has emerged in association with the SARS, later was named COVID-19 caused an environment of chaos worldwide and infected a massive number of lives. Since these epidemics or pandemics had spread to 210 countries and territories around the world and 2 international conveyances with 6,467,229 confirmed cases, including, 382,766 deaths, as of June 03, 2020 (https://www.worldometers.info/coronavirus/), hence the World Health Organization declared it as a global Public Health Emergency. There are no clinically approved vaccines or antiviral drugs available for either of new or old corona infections; thus, the development of effective therapeutic and preventive strategies that can be readily available to cope with these strains.
(© 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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