Evaluation of Angiopoietins 1 and 2 in Malaria-Infested Children.

Autor: Oluboyo AO; Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., Chukwu SI; Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., Oluboyo BO; Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., Odewusi OO; Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.
Jazyk: angličtina
Zdroj: Journal of environmental and public health [J Environ Public Health] 2020 May 26; Vol. 2020, pp. 2169763. Date of Electronic Publication: 2020 May 26 (Print Publication: 2020).
DOI: 10.1155/2020/2169763
Abstrakt: Background: Malaria could affect people of all ages, most especially young children. The study evaluated the levels of serum angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) which are critical regulators of endothelial activation and integrity with some hematological parameters (total white blood cell counts (WBC), total red blood cell counts (RBC), platelet counts, and malaria parasite density) in malaria-infected children.
Method: A total of 92 blood samples from children between the ages of 6 months to 15 years were analyzed. The samples consisted of 30 cases of severe malaria, 40 cases of uncomplicated malaria, and 22 apparently healthy subjects served as control. Serum Ang-1 and -2 levels were determined using the enzyme-linked immunosorbent assay technique. The hematological parameters were determined using the WHO standard.
Results: There was significant decrease ( p < 0.05) in serum Ang-1 of uncomplicated malaria and severe malaria compared with the control, while significant increase ( p < 0.05) was observed in Ang-2 and Ang-2/Ang-1 ratio in uncomplicated malaria and severe malaria compared with the control. RBC and platelet showed significant decrease, while WBC showed significant increase in severe malaria compared with uncomplicated malaria and control.
Conclusion: This study showed that subjects with malaria infection had a significant increase of Ang-2 and Ang-2 : Ang-1 ratio but presented with a significant decrease of Ang-1. Ang-1 and Ang-2 may be used to determine the severity of malaria infection since their levels differ significantly in malaria subjects compared with the control.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this article.
(Copyright © 2020 A. O. Oluboyo et al.)
Databáze: MEDLINE
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