Duffy blood group system and ocular toxoplasmosis.

Autor: Ferreira AIC; Universidade Federal de Roraima. Brazil; Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil., Brandão de Mattos CC; Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil., Frederico FB; Ophthalmology Outpatient Clinic of Fundação Faculdade Regional de Medicina de São José do Rio Preto, SP, Brazil., Bernardo CR; Universidade Federal de Roraima. Brazil., de Almeida Junior GC; Ophthalmology Outpatient Clinic of Fundação Faculdade Regional de Medicina de São José do Rio Preto, SP, Brazil., Siqueira RC; Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil., Meira-Strejevitch CS; Adolpho Lutz Institute, São Paulo, SP, Brazil., Pereira-Chioccola VL; Adolpho Lutz Institute, São Paulo, SP, Brazil., de Mattos LC; Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil. Electronic address: luiz.demattos@famerp.br.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2020 Nov; Vol. 85, pp. 104430. Date of Electronic Publication: 2020 Jun 19.
DOI: 10.1016/j.meegid.2020.104430
Abstrakt: Duffy blood group phenotypes [Fy(a + b-), Fy(a-b+), Fy(a + b+), Fy(a-b-)], characterized by the expression of Fy a , and Fy b antigens, are present in red blood cells. Therefore, we hypothesize that the non-hematopoietic expression of these antigens might influence cell invasion by T. gondii. 576 consecutive patients from both genders were enrolled. The presumed OT clinical diagnosis was performed. Duffy phenotyping was performed by hemagglutination in gel columns and for the correct molecular characterization Fy(a-b-) phenotype, using PCR-RFLP. Anti-T. gondii IgG antibodies were detected by ELISA. Chi-square, Fisher's exact tests were used to compare the proportions. OT was present in 22.9% (n = 132) and absent in 77.1% (n = 444) of patients. The frequencies of anti-T. gondii IgG antibodies were higher in OT (127/132, 96.2%) than those without this disease (321/444, 72.3%) (p < .0001). None of the Duffy antigens or phenotypes were associated with T. gondii infection (χ2: 2.222, GL: 3, p = .5276) as well as the risk of OT (χ2: 0.771, GL: 3, p = .8566). Duffy blood group system phenotypes and their antigens do not constitute risk factors for infection by T. gondii infection and the development of OT.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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