Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.

Autor: Firbank MJ; Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Nuns Moor Road, Newcastle upon Tyne, NE4 5PL, UK. michael.firbank@ncl.ac.uk., O'Brien JT; Department of Psychiatry, University of Cambridge, Level E4 Cambridge Biomedical Campus, Box 189, Cambridge, CB2 0SP, UK., Ritchie K; INSERM, Montpellier, France.; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK., Wells K; The Centre for Psychiatry, Imperial College London, 7th floor Commonwealth Building, Du Cane Road, London, W12 0NN, UK., Williams G; Department of Clinical Neurosciences and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK., Su L; Department of Psychiatry, University of Cambridge, Level E4 Cambridge Biomedical Campus, Box 189, Cambridge, CB2 0SP, UK., Ritchie CW; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2020 Nov; Vol. 267 (11), pp. 3282-3286. Date of Electronic Publication: 2020 Jun 20.
DOI: 10.1007/s00415-020-10000-8
Abstrakt: Background and Aims: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects.
Methods: A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM.
Results: Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this.
Conclusions: We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40-60-year-olds.
Databáze: MEDLINE
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