Recent advances in the role of interleukin-6 in health and disease.

Autor: Peppler WT; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada., Townsend LK; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada., Wright DC; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON, Canada. Electronic address: dcwright@uoguelph.ca.
Jazyk: angličtina
Zdroj: Current opinion in pharmacology [Curr Opin Pharmacol] 2020 Jun; Vol. 52, pp. 47-51. Date of Electronic Publication: 2020 Jun 18.
DOI: 10.1016/j.coph.2020.04.010
Abstrakt: Interleukin-6 (IL-6) is a pleotropic cytokine, and in this review, we highlight recent studies focusing on the role of IL-6 in health and disease. IL-6 is known as an exercise-inducible myokine, and in rodents it was identified that a lactate-dependent increase in protease activity mediates IL-6 release from skeletal muscle, which acts in both an autocrine and paracrine roles. In humans, a series of publications observed that blocking IL-6 during exercise training prevented beneficial adaptations, such as reductions in visceral and epicardial fat mass. Independent of exercise, IL-6 impacts postprandial physiology, as demonstrated by a slowing of gastric emptying rate and improving glucose homeostasis. Finally, an engineered cytokine harnessing the biology of IL-6, termed IC7Fc, was found to have beneficial impacts on numerous health outcomes. Together, these recent advances indicate that IL-6 has a multifaceted, and perhaps beneficial, role in health and disease.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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