Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy.

Autor: Aranda-Lara L; Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México, 50180, Mexico. Electronic address: larandal@uaemex.mx., Morales-Avila E; Laboratorio de Investigación en Farmacia, Facultad de Química, Universidad Autónoma del Estado de México, Toluca, Estado de México, 50120, Mexico. Electronic address: emoralesav@uaemex.mx., Luna-Gutiérrez MA; Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos-CONACyT, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México, 52750, Mexico. Electronic address: myrna.luna@inin.gob.mx., Olivé-Alvarez E; Centro de Isótopos, Avenida Monumental y Carretera 'La Rada', Km. 3 1/2, Guanabacoa, Ciudad de La Habana, Cuba. Electronic address: eunice.olive@gmail.com., Isaac-Olivé K; Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Estado de México, 50180, Mexico. Electronic address: kisaaco@uaemex.mx.
Jazyk: angličtina
Zdroj: Chemistry and physics of lipids [Chem Phys Lipids] 2020 Aug; Vol. 230, pp. 104934. Date of Electronic Publication: 2020 Jun 17.
DOI: 10.1016/j.chemphyslip.2020.104934
Abstrakt: Radiolabeled lipidic nanoparticles, particularly liposomes and lipoproteins, are of great interest as agents for imaging and therapy, due not only to their peculiar physicochemical and biological properties, but also to their great versatility and the ability to manipulate them to obtain the desired properties. This review provides an overview of radionuclide labeling strategies for preparing diagnostic and therapeutic nanoparticles based on liposomes and lipoproteins that have been developed to date, as well as the main quality control methods and in vivo applications.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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