| Autor: |
Graßmann S; Department Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany., Pivovarova-Ramich O; Research Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.; Department of Endocrinology, Diabetes and Nutrition, Charité-Universitaetsmedizin Berlin, 13125 Berlin, Germany.; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany., Henze A; Junior Research Group ProAID, Institute of Nutritional Science, Potsdam University, 14558 Nuthetal, Germany., Raila J; Physiology and Pathophysiology of Nutrition, Institute of Nutrition Science, Potsdam University, 14558 Nuthetal, Germany., Ampem Amoako Y; Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology (KNUST), P.O. Box 1934 Kumasi, Ghana., King Nyamekye R; Agogo Presbyterian Hospital, P.O. Box 27 Agogo, Ghana., Bedu-Addo G; Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology (KNUST), P.O. Box 1934 Kumasi, Ghana., Mockenhaupt FP; Institute of Tropical Medicine and International Health, Charité-Universitaetsmedizin Berlin, 13353 Berlin, Germany., Schulze MB; Department Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany., Danquah I; Department Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.; Heidelberg Institute of Global Health (HIGH), Universitaetsklinikum Heidelberg, 69120 Heidelberg, Germany. |
| Abstrakt: |
In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15'-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17-4.02) vs. 2.59 (2.21-3.50) µmol/L, p -value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa. |
