PI 3-kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNS.
Autor: | Nieuwenhuis B; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Laboratory for Regeneration of Sensorimotor Systems, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands., Barber AC; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Evans RS; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Pearson CS; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Fuchs J; Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany., MacQueen AR; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK., van Erp S; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Haenzi B; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Hulshof LA; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Osborne A; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Conceicao R; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Khatib TZ; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Deshpande SS; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Cave J; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Ffrench-Constant C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Smith PD; Department of Neuroscience, Carleton University, Ottawa, ON, Canada., Okkenhaug K; Department of Pathology, University of Cambridge, Cambridge, UK., Eickholt BJ; Institute of Biochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany., Martin KR; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Vic., Australia.; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Vic., Australia., Fawcett JW; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Centre of Reconstructive Neuroscience, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic., Eva R; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
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Jazyk: | angličtina |
Zdroj: | EMBO molecular medicine [EMBO Mol Med] 2020 Aug 07; Vol. 12 (8), pp. e11674. Date of Electronic Publication: 2020 Jun 17. |
DOI: | 10.15252/emmm.201911674 |
Abstrakt: | Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol (3,4,5)-trisphosphate (PIP (© 2020 The Authors. Published under the terms of the CC BY 4.0 license.) |
Databáze: | MEDLINE |
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