Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals.

Autor: White-Schwoch T; Auditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, IL, United States., Magohe AK; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Fellows AM; Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, Hanover, NH, United States., Rieke CC; Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, Hanover, NH, United States., Vilarello B; Auditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, IL, United States., Nicol T; Auditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, IL, United States., Massawe ER; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Moshi N; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania., Kraus N; Auditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, IL, United States. Electronic address: nkraus@northwestern.edu., Buckey JC; Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2020 Aug; Vol. 131 (8), pp. 1827-1832. Date of Electronic Publication: 2020 May 22.
DOI: 10.1016/j.clinph.2020.04.165
Abstrakt: Objective: To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions.
Methods: A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech.
Results: The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups.
Conclusions: Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds.
Significance: The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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