Toward Neurosubtypes in Autism.

Autor: Hong SJ; Center for the Developing Brain, Child Mind Institute, New York., Vogelstein JT; Department of Biomedical Engineering Institute for Computational Medicine, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, Maryland., Gozzi A; Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy., Bernhardt BC; McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Yeo BTT; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts; Department of Electrical and Computer Engineering, Center for Sleep and Cognition, Clinical Imaging Research Centre, N.1 Institute for Health, National University of Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore; Centre for Cognitive Neuroscience, Duke-NUS Medical School, Singapore., Milham MP; Center for the Developing Brain, Child Mind Institute, New York; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, New York., Di Martino A; Autism Center, Child Mind Institute, New York. Electronic address: Adriana.DiMartino@childmind.org.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2020 Jul 01; Vol. 88 (1), pp. 111-128. Date of Electronic Publication: 2020 Apr 22.
DOI: 10.1016/j.biopsych.2020.03.022
Abstrakt: There is a consensus that substantial heterogeneity underlies the neurobiology of autism spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of variation at the molecular, cellular, and brain network domains is a prerequisite for identifying biomarkers. Neuroimaging has been widely used to characterize atypical brain patterns in ASD, although findings have varied across studies. This is due, at least in part, to a failure to account for neurobiological heterogeneity. Here, we summarize emerging data-driven efforts to delineate more homogeneous ASD subgroups at the level of brain structure and function-that is, neurosubtyping. We break this pursuit into key methodological steps: the selection of diagnostic samples, neuroimaging features, algorithms, and validation approaches. Although preliminary and methodologically diverse, current studies generally agree that at least 2 to 4 distinct ASD neurosubtypes may exist. Their identification improved symptom prediction and diagnostic label accuracy above and beyond group average comparisons. Yet, this nascent literature has shed light onto challenges and gaps. These include 1) the need for wider and more deeply transdiagnostic samples collected while minimizing artifacts (e.g., head motion), 2) quantitative and unbiased methods for feature selection and multimodal fusion, 3) greater emphasis on algorithms' ability to capture hybrid dimensional and categorical models of ASD, and 4) systematic independent replications and validations that integrate different units of analyses across multiple scales. Solutions aimed to address these challenges and gaps are discussed for future avenues leading toward a comprehensive understanding of the mechanisms underlying ASD heterogeneity.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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