Long-acting approaches for delivery of antiretroviral drugs for prevention and treatment of HIV: a review of recent research.

Autor:	Cobb DA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., Smith NA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., Edagwa BJ; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA., McMillan JM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center , Omaha, NE, USA.; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center , Omaha, NE, USA.
Jazyk:	angličtina
Zdroj:	Expert opinion on drug delivery [Expert Opin Drug Deliv] 2020 Sep; Vol. 17 (9), pp. 1227-1238. Date of Electronic Publication: 2020 Jul 06.
DOI:	10.1080/17425247.2020.1783233
Abstrakt:	Introduction: Despite significant advances in treatment and prevention of HIV-1 infection, poor adherence to daily combination antiretroviral therapy (ART) regimens remains a major obstacle toward achieving sustained viral suppression and prevention. Adherence to ART could also be compromised by adverse drug reactions and societal factors that limit access to therapy. Therefore, medicines that aim to improve adherence by limiting ART side effects, frequency of dosing and socially acceptable regimens are becoming more attractive. Areas Covered: This review highlights recent advances and challenges in the development of long-acting drug delivery strategies for HIV prevention and treatment. Approaches for extended oral and transdermal deliveries, microbicides, broadly neutralizing antibodies, and long-acting implantable and injectable deliveries are reviewed. Expert Opinion: Emerging approaches on long-acting antiretroviral therapies and broadly neutralizing antibody technologies are currently at various stages of development. Such efforts, if successful and become broadly accepted by clinicians and users, will provide newer and simpler options for prevention and treatment of HIV infection.
Databáze:	MEDLINE
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