Mouse Ptchd3 is a non-essential gene.
| Autor: | González Morales SR; Department of Biology, Marshall University, Huntington WV25755, USA., Liu C; Department of Biology, Marshall University, Huntington WV25755, USA., Blankenship H; Department of Biology, Marshall University, Huntington WV25755, USA., Zhu GZ; Department of Biology, Marshall University, Huntington WV25755, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Gene: X [Gene X] 2020 Mar 13; Vol. 5, pp. 100032. Date of Electronic Publication: 2020 Mar 13 (Print Publication: 2020). |
| DOI: | 10.1016/j.gene.2020.100032 |
| Abstrakt: | Mouse Ptchd3 (patched domain containing 3) was previously identified as a male germ-cell specific gene. The protein product of this gene has been found on the surface of mouse, rat and human sperm. Since Ptchd3 contains a conserved patched domain, we hypothesize that it functions as a membrane receptor for the hedgehog ligand. Herein, we used a Ptchd3 knockout mouse model to study its function in mouse development and spermatogenesis. We found that Ptchd3 knockout mice were born and lived normally. The fertility and sperm production of knockout males were not changed. Moreover, our data indicated that the expression levels of several hedgehog signaling genes were not affected in mutant testis. Taken together, these findings demonstrate that Ptchd3 is a non-essential gene in mouse development and spermatogenesis. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2020 Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|